Last updated: December 26, 2020
The human body is efficient in that it regularly creates many of the substances it needs to be healthy and to function properly. These substances include hormones, chemicals, vitamins, and even cholesterol. These days, the word cholesterol carries with it a negative connotation due to “bad” cholesterol being one of the primary causes of cardiac and vascular disease. In general, “good” cholesterol and the vital roles that it plays within the body are often overlooked. So, what exactly is cholesterol - good and bad, how does it help us, and how does it cause disease? What preventive steps can we take to reduce our chances of developing a life-threatening disease caused by hypercholesterolemia? In this article, we will explore these answers and offer helpful tips and information regarding this subject.
Cholesterol is a waxy, oil-based substance that is found not only in the blood but also in all cells of the body. This substance, produced by the body, is not actually a kind of fat, but a sterol. A sterol is a naturally occurring group of solid, unsaturated alcohols found in plants and animals; the body cannot draw any energy from it because it contains no calories. This leads us to the question of if cholesterol is not a fat, how does it become detrimental to our health? The answer to this question is due to the difference between high-density lipoproteins (HDL) and low-density lipoproteins (LDL), which we will discuss shortly.
The human body creates the majority of the cholesterol that it requires; it produces roughly 80% while the remaining 20% is derived from a person’s diet. Cholesterol is primarily synthesized by the liver with about 20% of production occurring there. Other sites of synthesis include the reproductive glands, intestines and adrenal glands. Because the body monitors its own cholesterol levels, it will produce more if cells do not have enough. Dietary cholesterol is acquired through eating and is found in foods such as dairy products, red meat, poultry, pork, shellfish, eggs, and cheese.
Cholesterol in the body has five vital functions:
Because cholesterol is oil-based and does not mix with blood which is water-based, it is carried around the body by lipoproteins. Lipoproteins are quite literally fat(lipids) and soluble proteins, with proteins on the outside and lipids on the inside. There are two types of lipoproteins, LDL and HDL. Low-density lipoproteins (LDL) are frequently referred to as the "bad" type of cholesterol. LDL circulates in your blood and leaves fatty deposits which result in a buildup of plaque within the lining of your arteries. High-density lipoproteins (HDL) are viewed as the "good" type of cholesterol. HDL aids in keeping bad cholesterol away from your arteries by clearing away excess LDL found in the blood and then transporting it back to the liver. Once LDL is in the liver, it is removed by utilizing it for the production of bile acids which aid the intestines in the digestive process. Because HDL can assist with clearing away excess fatty deposits in the arteries, it is helpful in the prevention of cardiovascular disease.
Every adult should have their cholesterol checked at least once every five years as part of their yearly physical exam. This is done through a blood test called a lipid profile which measures a person’s total cholesterol along with individual LDL and HDL levels. A total cholesterol level is inclusive of both LDL and HDL levels. This test will help a physician determine a person’s level of cardiac risk, along with any other known risk factors for heart disease. The results of this test will also assist the physician in developing a plan of treatment and follow-up if needed.
The following table shows what the optimal, borderline and high cholesterol numbers are per healthcare industry standards. Do you know your numbers?
|Total Cholesterol||200mg/dL or less||200–239mg/dL||240mg/dL or higher|
|LDL - Bad cholesterol||Less than 100mg/dL||130–159mg/dL||160mg/dL and above|
|HDL - Good cholesterol||60mg/dL or higher - protective against cardiovascular disease||40–59mg/dL||Less than 40mg/dL - major risk factor for cardiovascular disease|
When a person’s total cholesterol or LDL numbers are too high, they may be diagnosed with hypercholesterolemia. Hypercholesterolemia is a condition that can result in serious health conditions such as coronary artery disease, peripheral artery disease, and cerebrovascular disease. The higher the LDL level is, the greater the risk. Inversely, the higher the HDL level, the lower the risk of developing cardiovascular disease.
One major complication of hypercholesterolemia is a condition known as atherosclerosis. Atherosclerosis, or the hardening and narrowing of the arteries, is caused by the buildup of cholesterol plaques along the inner lining (endothelium) of the arterial walls. These plaques are usually able to form and adhere to the vessel wall after damage to the endothelium has occurred by other factors that include smoking, high blood pressure, diabetes, and more. When LDL attaches to the arterial wall it causes inflammation; in response, the body will send white blood cells (macrophages) to attack the cholesterol. Over a period of time the combination and accumulation of cholesterol and white blood cells (both active and dead), along with calcium and other crystallized materials, will build up and create atherosclerotic plaque. This buildup of plaque can significantly reduce blood flow causing some disease states.
Atherosclerosis is a chronic, cumulative and slowly progressive condition that may remain asymptomatic for many years. Once atherosclerotic plaque has significantly reduced blood flow within an artery it can wreak major havoc on the body, depending on its location. There are three common conditions caused by atherosclerosis:
An additional complication of cardiovascular disease is the potential development of an aneurysm. An aneurysm is a localized bulge caused by the weakening of an arterial wall which can occur can occur anywhere in the body. If an aneurysm ruptures, it can cause a life-threatening emergency due to internal bleeding.
Hypercholesterolemia by itself is usually asymptomatic, meaning that it does not present any signs or symptoms. Often it is not until an adverse event occurs, such as the threat of a heart attack or stroke, that testing is done to confirm this condition. Routine lipid profiles should be conducted for those who are considered to be at a higher risk. Various factors, both modifiable and non-modifiable, determine who is at the highest risk of developing high cholesterol and cardiovascular disease.
Non-modifiable risk factors tend to be genetic and include:
Modifiable risk factors include:
Reducing the chances of developing a condition associated with high cholesterol begins with each individual. Obviously, some factors are out of a person’s control, but every step that is taken to lower LDL levels will assist in slowing or stopping the process of plaque formation. Living a healthy lifestyle will not remove plaque or blockages that have already formed, but it can prevent further progression. Most people can lower their cholesterol levels by:
Maintaining a healthy lifestyle, eating a healthy diet and regularly exercising is sometimes not enough for some individuals. For those who find themselves in this situation, cholesterol-lowering medications may help. After a full assessment by a licensed physician, they may prescribe a single drug or a combination of drugs to lower LDL and increase HDL. Most often, the first type of drug a physician will prescribe is called a statin; statins lower LDL and triglycerides, a different type of blood fat. This kind of drug is also helpful in the prevention of heart attacks by increasing the stability of the blood plaque to the scarred tissue thanks to balancing done to the amount of cholesterol and scar tissue.
Commonly prescribed statins include:
The following are other types of drugs commonly prescribed:
|Type of drug||Name of drug||Used for|
|Prescription B vitamin||Niacin||Decreasing LDL and increasing HDL|
|Combination statin and niacin||Niacin-lovastatin||Lowering LDL and increasing HDL|
|Cholesterol absorption inhibitor||Ezetimibe||Decreasing LDL and slightly increasing HDL|
|Bile acid binding resins||Cholestyramine, colestipol, colesevelam||Decreasing LDL|
Because atherosclerosis by itself is usually asymptomatic, some individuals may not know they have cardiovascular disease until an adverse event occurs. These events can range anywhere from angina to a major heart attack or stroke. When this happens, a physician will perform a series of tests to determine the location and severity of the blockage. Depending on these results, different procedures can be conducted to unblock the affected arteries.
The following is a simple list of procedures that are commonly performed:
According to the World Health Organization, 17.5 million people die each year as a result of cardiovascular diseases which are an estimated 31% of all deaths worldwide. 80% of these deaths are due to heart attack and stroke. With these statistics, prevention of high cholesterol and cardiovascular disease should be a priority for every individual.
See also our Guide to a Healthy Heart for more advice on heart health.